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Role of telomeres alterations in chronic lymphocytic leukemia

Biology of Telomeres Telomeres are specific non-coding nucleotide sequences located at the ends of eukaryotic chromosomes. They are necessary for the complete replication and stability of the chromosome. The replication of the lagging strand of the double DNA helix requires the presence, at the replication fork, of a certain number of nucleotides in front of […]

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B-Cell prolymphocytic leukemia

B-cell prolymphocytic leukemia (B-PLL) is a disorder characterized by proliferation of neoplastic B prolymphocytes in the peripheral blood, bone marrow and spleen (Campo E et al, 2008) which represent, by definition, more than 55% of lymphoid cells. B-PLL is not the transformation of chronic lymphocytic leukemia, as previously thought, and it represents a distinct biological entity […]

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Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) was for many years considered an indolent disease caused by the accumulation of small lymphocytes with disturbed apoptosis. Today the comprehension of the pathogenesis has modified this historical view and allowed the condition to be recognized as a dynamic disease, which originates from a wide range of primary and secondary biological […]

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