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Acute promyelocytic leukemia in adult patients

Epidemiology and diagnosis Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with peculiar morphologic, cytogenetic, and biomolecular characteristics (1). Most patients are young, present with leukopenia, and exhibit a life-threatening coagulopathy, which is the most relevant manifestation of the disease at diagnosis (2). The disease is relatively rare in adults, […]

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Acute myeloid leukemia

AML is a clonal proliferation of hematopoietic stem cells characterized by blocked or severely impaired differentiation of the hematopoietic stem cell, resulting in an accumulation of cells at various stages of incomplete maturation with an associated reduced production of normal hematopoietic elements. As a consequence, various levels of cytopenia usually occur and the clinical manifestations […]

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